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The phosphorylation of Src and Cav-1 is an important process that mediates the endocytosis of VEGFR2 and triggers the eNOS activation in vascular endothelial cells 19,20

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Clinical uses of MET inhibitors in chemoresistance As discussed above, a number of clinical trials have evaluated MET inhibitors as a monotherapy against other targeted therapies or standard of care chemotherapy regimens (see Table 1)

Data are presented as the mean SD of three or four biological replicates in three or four independent samples

Practical Application as Support The evidence reported for the BPC 157 is the effectiveness with peptide given alone (Sikiric et al., 1993