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Of note, GLS1 inhibition causes an elevation of the ROS level and induces GPT2 expression via ATF4, which again implies the importance of ATF4-mediated metabolic adaption during glutamine starvation

319,321 Collectively, the ability of HSP70 and HSP90 to engage multiple aggregation-prone client proteins across distinct NDDs underscores their central role in neuronal proteostasis and highlights their broad therapeutic potential

Transl Psychiatry 6(11):e961e961 Mollner KL (2022) Global impacts of legalization and decriminalization of marijuana and cannabis

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The fact that these enzymes are reduced in dimorphic pathogenic Ajellomycetaceae but not in H