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Under low-energy conditions where the AMP/ATP ratio increases, thus PGC-1 can be activated by phosphorylation by AMPK, or the NAD + /NADH ratio description triggers PGC-1 deacetylation by SIRT1 activation

developed a tolerance-inducing vaccine based on antioxidant lignin nanoparticles that can efficiently encapsulate dexamethasone (Dex) and conjugate MOG peptides for the treatment of multiple sclerosis [38]