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These systems often deliver antigens and adjuvants or cyclic dinucleotide STING agonists within lipid or polymeric carriers, aiming to enhance dendritic cell uptake, support type I interferon responses and improve the depth of response when combined with checkpoint blockade [76, 77, 81]

Outcomes would be measured with validated instruments: instrumental elasticity and firmness, corneometry and cutometry, standardized photography with blinded grading, and, most convincingly, dermal biopsies quantifying collagen density and organization before and after

6C, left ) by electric stimulation of the Schaffer collaterals

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In addition, it has been demonstrated that the interaction between IL-1 receptors and NMDARs can also lead to increased excitotoxicity, and the expression of IL-1 receptors on the postsynaptic membrane is stimulated by NMDAR activation (Gardoni et al., 2011)