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In addition, IL4R is highly expressed in M2-polarized, protumoral TAMs compared with M1-polarized, antitumoral macrophages, making IL4R a potential target for targeted drug delivery to TAMs 31,32

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Conclusion: These results demonstrate the promise of ML-based models in capturing high-risk features, ultimately enabling a more targeted diagnostic and therapeutic approach

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10.1186/s12951-015-0101-9 J