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INTRODUCTION The prevalence of chronic kidney disease (CKD) is an issue for global public health

The blood-brain barrier (BBB), is a tightly regulated system composed of transporters including permeability-glycoprotein (Pgp) and ATP-binding cassette sub-family B member 1 (ABCB1)

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However, these levels could be restored through the administration of liproxstatin-1 (Lip1), a free radical scavenging antioxidant and thus a potent inhibitor of ferroptosis 41 (Fig