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In the function of substrate and products, k 2 denoted the thermodynamic constant representing the ratio between the concentrations of the products and the substrates at equilibrium while K S and K P denoted the Michaelis constants for the substrate and the production for the underlying reaction, respectively

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R J Maude reports support for the present manuscript from Wellcome Trust (grant 220211) as it provides core funding for Mahidol Oxford Tropical Medicine Research

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