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GLP-1 receptor agoniststhe class of drugs that includes semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)are synthetic molecules engineered to mimic and amplify this exact hormonal signal

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The second barrier to an amylin-analog drug was to extend the half-life relative to the first-generation drug, pramlintide, which is injected 3 times daily

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doi: 10.1038/s41443-019-0186-z 31 BelewDKlaassenZLewisRW