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The same group also demonstrated that increased intestinal permeability occurred in a sub group of alcohol-dependent subjects which were associated with higher depression and anxiety scores as well as an altered gut microbiota profile (Leclercq et al., 2014b)

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Clinical evidence suggests that total parenteral nutrition supplemented with glutamine improves nitrogen balance, maintains the intracellular glutamine pool, enhances protein synthesis, and prevents deterioration of gut permeability in post-surgery patients (12)