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Regulation of ChaC1. Oxidative and ER stress, and viral infection Download Scientific Diagram The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2: Cell Reports Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element* Journal of Biological Chemistry A scheme of the mechanism of CHAC1 degradation of glutathione enhancing Download Scientific Diagram TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione degrading enzyme CHAC1 ScienceDirect
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