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In the colon, only a few macrophages were observed in the submucosal layer on the 3rd day after DSS treatment, but on the 5th day, many macrophages were observed in the mucosal and the submucosal layer where the colon plicae had collapsed (Fig

doi:10.1016/j.placenta.2010.02.011

Sixthly, the pathogenic mechanisms of diseases are exceedingly complex, involving genetic factors, environmental influences, and numerous unknown variables

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These opposing roles of distinct PRDX isoforms suggest that PRDXs function not simply as antioxidant enzymes but as context-dependent determinants of ferroptosis sensitivity