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The pro-inflammatory cytokine TNF is another candidate as a potential biomarker as it is increased in CSF levels in AD patients (Llano et al., 2012) and is associated with increased cognitive decline in AD patients with systemic infection (Holmes et al., 2009)

Int J Immunopharmacol 1998

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However, these reactions invariably result in the generation of reactive oxygen species (ROS) compounds that are unstable by having final layer of electrons unpaired and that, in trying to stabilize itself sequester electrons from other biomolecules, making them also destabilizes and, therefore, is no longer able to perform their duties properly, thus altering the homeostasis and, ultimately, causing cell death