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Foundational research also supports the role of microglia in A uptake and degradation, mediated by specific receptors and enzymatic pathways, alongside associated neuroinflammatory responses observed in AD pathology ( In Alzheimers disease brains, inflammation is particularly prevalent around A plaques (Wang et al., 2023

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Among the several types of conjugation reactions which are present in the body, including glucuronidation, sulfation, and glutathione and amino acid conjugation, glutathione which is catalyzed by glutathione S-transferases, is the major phase II reaction in many species [52]

Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond

10.1089/ham.2019.0126 54 LiaoY.ChenZ.YangY.ShenD.ChaiS.MaY.et al (2023)