Cellular distribution studies of the nitric oxide-generating antineoplastic prodrug O(2)-(2,4-dinitrophenyl)1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate formulated in Pluronic P123 micelles
Description During this lesson (making salts) KS3 / Junior High students work through a variety of activities to develop their understanding of what products are formed from neutralisation reactions
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For further biological evaluation, co-culture systems and reconstructed skin models should be adopted to screen for the ability of the novel compounds to interfere with the melanogenesis process, especially following stimuli including UV irradiation, exposure to a-MSH or proinflammatory cytokines
