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human lifespan trials do not)6 Optimal dosing windows, cycling duration, and rest intervals for stacked protocols The Frontiers in Aging 2026 review stated the limitation clearly: significant knowledge gaps include optimal dosing regimens, combination therapy effects, and biomarkers for monitoring efficacy.2 This is why supervised clinical protocols with regular lab monitoring and dose titration are not optional

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Therapeutic strategies that concurrently target these interrelated systems may yield superior outcomes compared to monotherapies

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Menzies et al., 2020) which may contribute to the elevated oxidative stress, inflammation, and metabolic dysfunction observed in these conditions