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In contrast, the inhibition of SIRT1 significantly diminished the protective effects of melatonin, suggesting that melatonin plays a crucial role in maintaining mitochondrial function to suppress oxidative stress by modulating the level of SIRT1 in OA progression (137)

In the CNS, MeHg exposure for 3 weeks in a rodent model promoted angiotensin-induced vasoconstriction in isolated basilar arterial

4a,b and Supplementary Fig

Following an 8-week intervention period, the ATD cohort demonstrated the most pronounced enhancement in femoral BMD and serum 25(OH)D concentrations, in addition to the most considerable decrease in PTH levels