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Authors and Reviewers Originally written in 2002 by: Jane Higdon, Ph.D

364 In an APP/PS1 mouse model of AD that carries human AD-linked mutations in APP and PSEN 1 genes, UA restored neuronal mitophagy, ameliorated cognitive decline, reduced A pathology, and mitigated neuroinflammation

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By localizing therapy to sites of neurodegeneration, these strategies mitigate peripheral side effects and circumvent BBB limitations

This unbalanced regulation of the glutathione oxidation/reduction cycle indicates the existence of an alternative pathway to regenerate GSH from GSSG to maintain a stable GSSG/GSH ratio