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10.5334/aogh.4163 [PMC free article: PMC10289045] [PubMed: 37362827] [CrossRef] Gold EB, Gordis L, Diener MD, Seltser R, Boitnott JK, Bynum TE, et al

Additionally, macrophages exhibit synergistic characteristics of dynamic phenotypic conversion and functional remodeling in response to DAMPs: during the acute injury phase, DAMPs (such as high-mobility group box protein B1 and adenosine triphosphate) activate the Toll-like receptor 4/P2X7 receptor pathway, which in turn activates the NF-B and NLRP3 inflammasome, driving macrophages toward M1 polarization and the secretion of pro-inflammatory factors such as interleukin-1(IL-1) and tumor necrosis factor- (TNF-), thereby establishing an efficient pathogen clearance mechanism (Gong et al., 2020) (86)

5-Amino 1MQ has been studied for its potential to interact with NNMT-related pathways

Adipose mesenchymal stem cell derived exosomes promote keratinocytes and fibroblasts embedded in collagen/platelet-rich plasma scaffold and accelerate wound healing

doi: 10.1080/10408444.2019.1692191