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Three cysteine residues (Cys47, Cys177, and Cys271) are located in the substrate-binding site of GSNOR highlighted in the three-dimensional structure of Arabidopsis GSNOR ( Figure 6B )

The low response rate of lenvatinib, which is mostly caused by resistance development, limits its practical utility in treating patients with advanced liver cancer, even though it is the recommended initial treatment for this condition

Function of several critical amino acids in human pyruvate dehydrogenase revealed by its structure

2002 Jul;23(6):497-502

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