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However, the development of DKD is intimately associated with pathologically driven mTORC1/p70S6K signaling, which may further induce DKD complicated by RTEC transdifferentiation (130)

G.ChenP.ChalmersB.DriskoJ.SunA

The primary goal of current treatment methods remains centered on symptom alleviation, achieved by making up for the loss of neurotransmitters, such as acetylcholine in Alzheimers disease using established cholinesterase inhibitors (ChEIs), and dopamine in Parkinsons disease through the use of dopamine precursors or agonists

ROS also attack unsaturated fatty acids in cell membranes and lipoproteins, triggering lipid peroxidation that compromises membrane integrity and fluidity [109]

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