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Argininosuccinate synthetase (AS) represents a potential translational protein liver injury biomarker that was initially observed by Svetlov et al

Gao, C.Y

This shift is further promotedespecially in visceral depotsby accumulation of CD8 + Tc1 and CD4 + Th1 cells (IFN-), by Th17 enrichment, and by a relative decline in regulatory T cells (Tregs) [944,945,946,947,948,949,950]