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Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

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4.4 Future perspectives: from mechanistic insight to clinical translation To fully harness the therapeutic potential of ferroptosis in kidney diseases, future research must address the aforementioned challenges through a combination of mechanistic depth, technological innovation, and clinical validation

GA combined with ursodeoxycholic acid can significantly reduce liver enzyme levels within 12 weeks and enhance the effectiveness of treatment for MASLD

doi: [Google Scholar] 3.Chen J, He W, Yang Z