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Another study in the Journal of the American Medical Association notes that among those with diabetic nephropathy (loss of kidney function due to diabetes), combining vitamin B6 (25 mg) and folic acid (2.5 mg) (B-complex vitamin) with 1,000 mcg of oral B12 per day for six years increases the risk of cardiovascular events, including heart attack and stroke

While its true that receptor density can change due to various factors, its an oversimplification to suggest that this change is the direct cause of increased pain or sensations in B12-treated individuals

The day 3 sample showed a weak but specific IgG response that presumably pre-dated phage administration, but at both day 17 and week 16 post-phage initiation there was a robust IgG-mediated response, comparable to that reported in a prior patient 15

While I cant say exactly how much you should be using I can give you some pertinent information that will help guide you

[email protected] Christine B Phillips MBBS, MA, MPH, FRACGP, ACT Refugee Health Service