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PERK promotes eIF2 phosphorylation after dimerization and trans-autophosphorylation, subsequently inducing ATF4 synthesis and translocation

These results imply that OXY might be a viable curative option for testicular dysfunction and male infertility resulting from acute inflammatory disorders

A milestone in LHON treatment has been the approval of idebenone in 2015 ( Idebenone is a synthetic short-chain analogue of ubiquinone with anti-oxidant properties [10], which has shown to increase the rate of visual recovery in LHON patients, especially when given in the acute stage [11, 12]