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Nevertheless, cGAS has been found to directly suppress DNA repair [76, 77], mechanistically in tumorigenesis by directly binding cGAS to DDR components inside the cell nucleus

Koppe T, Patchen B, Cheng A, Bhasin M, Vulpe C, Schwartz RE, Moreno-navarrete JM, Fernandez-real JM, Pissios P, Fraenkel PG (2017) Nicotinamide N -methyltransferase expression decreases in iron overload, exacerbating toxicity in mouse hepatocytes