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Our results demonstrated that GAE and its active constituent DMB could inhibit TNBS-induced UC, reducing inflammatory response and alleviate colon muscle spasm, suggesting that DMB may be a good candidate for subsequent development as a multitargeting drug for UC treatment

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It was found that berberine reduced the expression of toll-like receptor 4 (TLR4), Src family tyrosine kinase (LYN), phatidylinositol 3-kinase (PI3K), NF-B, TNF- , IL-1, and caspase-3, which was accompanied by a reduction in cell apoptosis, which pointed to the potential significance of berberine in the therapy of PCOS (123)

Simultaneously, persistent cytokines activate adaptive immune responses, further exacerbating inflammation within the joint ( Additionally, based on the presence or absence of anti-CCP antibodies/RF positivity in the serum, RA can be classified into seronegative RA (SNRA) and seropositive RA (SPRA) ( The study by Zhang F et al

GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling