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These growth abnormalities in LS patients without IGF-I substitutive treatment includes postnatal average growth rates of one-half the expected during the first years of life [19], a small brain (with prominent forehead, reduced vertical dimension of the face and hypoplasia of the midfacies and the nasal bridge), a small heart and acromicria [203] together with underdevelopment of the muscular system that delays walking in three-fourth of patients [204,205], osteopenia at all stages (despite normal sex hormone status) with increased occurrence of avascular necrosis of the femoral head [206], impair and weaken skin, hair and nail growth [207], blue sclera due to the decreased thickness of its connective tissue, allowing visualization of the underlying choroid [205], a puberty delay from 3 to 7 years [206], retardation in the maturation of dentition [206] and high-pitched voice [208]

In: Weinberger DR, Harrison P, editors

It has also shown efficacy in preventing severe pneumonia, potentially by acting on the IL-6 trans signal and HM-GB1 system (426)

Nevertheless, these findings need to be interpreted with caution and replication in a larger randomized controlled trial is needed

For menopausal women, collagen does offer additional benefits for skin, joint, and bone health, making it a reasonable addition rather than a replacement for standard protein sources