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These results suggest that both low and high copper levels induce oxidative stress, with HepG2 ATP7B-KO cells being more sensitive under physiological copper conditions

Trophoblasts, in the process of connecting with maternal blood vessels, accelerate villi formation while expanding their surface area, which leads to increased intervillous space perfusion: OS levels are thus increased, triggering the expression of heat shock protein (hsp60 and hsp70), which results in retardation of fetal development and possible pregnancy failure [36]

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In mice, beta-carotene co-administration led to increased tumor growth delay with doxorubicin and etoposide, and increased tumor cell killing with cyclophosphamide in solid tumors