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Most recently, attention has shifted to proteosomal degradation of AR, with AR-targeting PROTACs being tested as a novel therapeutic option, and with drugs that possess a dual action as AR degrader and as AR antagonist under development [24, 25]

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doi: 10.3389/fimmu.2020.01007 Received 21 February 2020 Accepted 28 April 2020 Published 28 May 2020 Volume 11 - 2020 Edited by Laxmi Yeruva, University of Arkansas for Medical Sciences, United States Reviewed by Barbara Wrblewska, Institute of Animal Reproduction and Food Research (PAN), Poland

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Wu and Gao, 2018), indicating that the effects of GH and IGF1 on cell proliferation can not only maintain the growth and development of normal organism, but also promote the process of cancer cells