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In a previous clinical study 27,28 , we evaluated implants engineered from recombinant human collagen that had several limitations: the collagen could be produced only in small quantities, implants were mechanically weak and required invasive suturing, implants were not evaluated for long-term stability, and surgery was invasive and led to a strong wound-healing response and partial implant melting

Administration Route Considerations: Intra-articular injection ensures direct delivery to joint tissue but requires medical expertise and proper sterile technique

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Cadmium is not an essential element, so it does not enter the body through a specific transport system (35)

The traditional way of diagnosing vitamin B12 deficiency has been with a serum B12 blood test to determine the patients B12 levels as well as the presence of any signs or symptoms of pernicious anaemia