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Long-term results with 1,030 patients

The SIRT1/Nrf2/GPX4 pathway was identified as a protective mechanism, with SIRT1 knockdown reversing this effect

10.1016/j.jmu.2015.02.001 J

eCl 2016;4:31-5

Hormonal changes : Menopause, along with other hormonal fluctuations, can affect skin quality, potentially increasing patchiness and hyperpigmentation