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10.1038/s43247-025-02169-5 193 HsiaoC

In summary, the problem in aging and most chronic disease is that our cells lose the ability to make enough Glyteine which results in insufficient glutathione production

Biochemically, GGT is associated directly with GSH regulation and maintenance of its normal redox status in cells by breaking down extracellular GSH which cannot cross the cellular membrane to release cysteine and glycine building blocks which can more easily cross into the cell for de-novo synthesis of GSH during periods of oxidative stress [26]

Pair-fed control (CON) mice received a LD diet in which the EtOH content was substituted by carbohydrates

Furthermore, transcriptomic sequencing analysis, combined with in vivo and in vitro experiments was performed to elucidate the efficacy and mechanism of GR in alleviating NAFLD