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Bose P, MD, Masarova L, MD, Pemmaraju N, MD, Bledsoe SD, Daver N, MD, Jabbour EJ, MD, Kadia TM, MD, Estrov ZE, MD, Kornblau SM, MD, Andreeff M , MD, PhD, Cortes JE, MD, Jain N, MD, Borthakur G, MD, Alvarado Y, MD, Huynh-Lu J, Assistant P, Nguyen-Cao MM, Assistant P, Richie MA, Dobbins MH, McCrackin SA, Zhou L, Pierce SA, BSN, BA, Wang X, MS, Pike AM, RN, Garcia-Manero G, MD, Kantarjian H, MD, Verstovsek S, MD, PhD

Methodology Active Site Identification The active site inside the co-crystallized complex of glutathione reductase (GR) was predicted in using the CASTp (Computed Atlas of Surface Topography of Proteins) online server (Tian et al., 2018)

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Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse

When combined with immunotherapy, the intake of a KD can reshape the TME by increasing the population of CD8 + TILs, macrophages and CD86 + DCs