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Endocrinology 142, 34263434

Ramli et al., 2022

Another NAM analog-based NNMT inhibitor, 6-methoxy NAM (also known as JBSNF000088), has shown promise in decreasing body weight and enhancing insulin sensitivity in mice models of obesity induced by a high-fat diet 198

Mesna detoxifies urotoxic metabolites formed from these two agents (e.g., oxazaphosphorine and acrolein), and by doing so, decreases the risk of bladder bleeding