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reported that AS-IV reduces the amplitude of L-type Ca 2+ current in guinea pig ventricular cells in a concentration-dependent manner, influencing L-type Ca 2+ channel kinetics, suppressing channel activity, and blocking Ca 2+ current, while concurrently inhibiting K + current to prolong APD (Zhao et al., 2013)

Interim necropsies are conducted at predetermined intervals to assess early pathological changes, while hematological and biochemical analyses at three, six, and twelve months provide key insights into systemic toxicity