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Ophthalmic Activity Following topical application to the eye, ketorolac inhibits miosis by inhibiting the biosynthesis of ocular prostaglandins

To determine whether other classes of anti-vascular therapy can reduce cords that are insensitive to VEGF inhibition, a broad spectrum anti-angiogenic antagonist (suramin), a vascular disrupting agent (combretastatin), and a combination therapy of a VEGFR-2 inhibitor (ramucirumab) and a gamma secretase inhibitor (GSI