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In situations without a major inflammatory component, the difference may be minimal

Adults who are ready to make lifestyle changes, such as diet and activity, and follow-up care

USA 95 , 25522557 (1998)

Since the simple act of feeding induces ER stress independent of dietary fat content, at least in the liver (Gomez and Rutkowski, 2016), it is possible that the consequences of obesity on ER function depend on whether or not the stimulus is experienced as accelerated feeding and fasting cycles, as in ob/ob mice, or as more calorically potent episodes of feeding with relatively normal frequency

Multiple scales and variations of the barbed needles were designed and used to explore the size-scale effect on the insertion force [54]