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The primary outcomeweight losswas negative: the AOD-9604 treatment groups demonstrated no statistically significant reduction in body weight compared to placebo

[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function

doi: 10.3389/fcvm.2021.756810 108