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The detoxification reactions comprise the first four steps of mercapturic acid synthesis, [19] with the conjugation to GSH serving to make the substrates more soluble and allowing them to be removed from the cell by transporters such as multidrug resistance-associated protein 1 (MRP1)

[46] If placed with proper aseptic technique, it is not recommended to change a peripheral IV line more frequently than every 7296 hours

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