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Such upregulation of MMPs and VEGF is primarily responsible for remodeling of the ECM matrix

-syn, a small soluble protein (140 amino acids) encoded by the SNCA gene, is widely recognized as a central component in the pathogenesis of PD

This is compensated in vivo by a simultaneous attack of a cocktail of components (defensins, cathelicidins) that disrupt the membrane integrity

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