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The resulting ROS promotes HSC activation, upregulates collagen I and -SMA, and perpetuates ECM accumulation [65]

[114] This functionality is lost in vitamin B 12 deficiency, and can be measured clinically as an increased serum methylmalonic acid (MMA) concentration

But there is another important use of collagen

Most recently, modalities such as HIFEM, RF, and TPE have emerged in esthetic practices

HYGIENE A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES A61K39/00Medicinal preparations containing antigens or antibodies A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant A61K2039/55505Inorganic adjuvants AHUMAN NECESSITIES A61MEDICAL OR VETERINARY SCIENCE