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The adverse effects of aspirin such as tinnitus, Reyes syndrome and gastrointestinal bleeding are caused due to conversion of aspirin into its active metabolite salicylic acid after oral intake

10.1021/acs.chemrev.8b00626 77 YangN.XiaoW.SongX.WangW.DongX

Oxidants in chronic kidney disease

The idea behind step gradients is to control individual compound elution as much as possible in an effort to maximize the separation between compounds