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The S100A7/E-FABP complex is also involved in lipid transport and metabolism during epidermal barrier formation, and modulation of cell differentiation and migration in some dermatoses such as psoriasis (31, 68, 84)

Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro

The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

The 28-day window already accounts for minor temperature fluctuations within the approved range

Three studies showed the skin-lightening effect of a LiP-based cream, using a two-step protocol (first the enzyme product, second the activator H 2 O 2 ), with no observable adverse effect [195]