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Although these studies report promising results regarding the sublingual route, it is important to note that almost all of them only include patients with mild, subclinical B12 deficiency, making it difficult to extrapolate their outcomes for patients with severe deficiency or malabsorptive states

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After the reduction of GPX4 activity, the production of intracellular ROS increases and ROS accumulation occurs, which aggravates the occurrence of intracellular lipid peroxidation, and induces the occurrence of ferroptosis (Kim et al., 2021)

doi: 10.1016/j.tins.2020.09.011 250 QuadtLCritchleyHDGarfinkelSN

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