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The use of sdAbs such as [ 68 Ga]Ga-NOTA-Nb1053 allows same-day imaging one hour after injection with high target-to-background ratios, avoiding concerns associated with non-specific bone accumulation seen with 89 Zr-labeled mAb immunoPET techniques

The study also developed reliable methods for detecting AOD9604 in biological samples, which has applications in sports anti-doping testing since growth hormone fragments have been misused by athletes seeking performance enhancement

When used in combination with AOD 9604, they may produce a synergistic effect, further enhancing the effect of axunge breakdown and burning