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The introduction of biosimilars had major socioeconomic impact, giving the opportunity to increased use of anti-TNF- therapies worldwide

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For Bolamans study, there was also an increase in serum vitamin B12 levels in both groups (oral vitamin B12 1000 g vs

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B12 injections supply vitamin B12 as methylcobalamin or cyanocobalamin, typically given intramuscularly into the deltoid, supporting red blood cell formation, myelin and nervous system health, and the metabolism of homocysteine, a process that can falter with vegan diets, malabsorption, or medications like metformin