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222 By selectively targeting cancer cells with copper ionophores like Elesclomol or ROS-inducing agents, including radiotherapy or combination therapy, cuproptosis can be triggered, offering a promising strategy to overcome cancer

To elucidate the role of METTL3 in MASLD, we established a stable cell line overexpressing METTL3 in AML12 liver cells

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First-pass metabolism occurs when a compound is absorbed from the gut and passes through the liver, where it can be partially broken down before reaching the rest of the body

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