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Current therapeutics strategies under development The existence of mouse models in the NF1 arena (Box 2) has provided unprecedented opportunities to derive important insights into the biology of the disease as well as preclinical models that guide the development of effective therapies for NF1 (Fig

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Similarly, at sub-toxic levels, oxidants such as hydrogen peroxide, which can be generated directly by xanthine oxidase and certain NADPH oxidases or by dismutation of superoxide, mediate a plethora of redox-dependent pathways related to calcium signaling, protein phosphorylation, and transcription factor activation (Suzuki et al., 1997)