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Droxidopa can also cross the blood brain barrier, and hypothetically may be useful in patients with various CNS disorders

10.1021/ja067699e J

126 In liver fibrosis models, SIRT1 activation reduces Th2-derived pro-fibrotic cytokine levels

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Sim et al., 2007, 2014) and is expressed in fetal and neonatal tissue, while NAT2 is not expressed until approximately a year later (Pacifici et al., 1986