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CagriSema produced unprecedented mean weight loss of 20.4% at 68 weeks on an intent-to-treat basis, significantly exceeding semaglutide alone (14.9%), cagrilintide alone (11.5%), and placebo (3.0%)

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Melatonin regulates MSCs via paracrine mechanisms, controls ROS generation, promotes cell proliferation by inducing the expression of SRY-box transcription factor 2, and modulates immune responses, all contributing to enhanced MSC survival and function

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